Menopausal symptoms
Some trials report reduced hot flush frequency with soy isoflavones, with the effect concentrated in people whose gut bacteria produce equol, and with large placebo responses complicating interpretation.
Moderate evidence. Several human studies point the same way, with real caveats.
4 sources
- Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.(opens in a new tab)
Meta-analysis · In vivo (Athens, Greece) · 2022 · PMID 35241506
- Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.(opens in a new tab)
Meta-analysis · Advances in nutrition (Bethesda, Md.) · 2025 · PMID 39433088
- Isoflavone Supplements for Menopausal Women: A Systematic Review.(opens in a new tab)
Systematic review · Nutrients · 2019 · PMID 31689947
- Evaluation of Clinical Meaningfulness of Red Clover (Trifolium pratense L.) Extract to Relieve Hot Flushes and Menopausal Symptoms in Peri- and Post-Menopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.(opens in a new tab)
Meta-analysis · Nutrients · 2021 · PMID 33920485
Deep research mode adds each paper’s own conclusion and stated limitations.