Bone mineral density
Research suggests vitamin K2 intake is associated with bone density and turnover markers, with several Japanese trials and cohorts reporting benefit at natto-level intakes. Results outside Japan have been less consistent and fracture data remains limited.
What may be going on: Vitamin K2 is the cofactor that carboxylates osteocalcin, the protein that binds calcium into bone matrix.
Moderate evidence. Several human studies point the same way, with real caveats.
3 sources
- Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.(opens in a new tab)
Meta-analysis · Frontiers in public health · 2022 · PMID 36033779
- [Vitamin K2].(opens in a new tab)
Systematic review · Clinical calcium · 2008 · PMID 18830045
- The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a systematic review and meta-analysis.(opens in a new tab)
Meta-analysis · Frontiers in endocrinology · 2025 · PMID 41268154
Deep research mode adds each paper’s own conclusion and stated limitations.