Menopausal symptoms
Some trials report reductions in hot flush frequency with soy isoflavone intake, but results vary widely, partly because only some people carry the gut bacteria that convert daidzein to equol. Tempeh specifically has rarely been the tested food.
Limited evidence. Early human work, or mostly lab and animal research.
3 sources
- Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.(opens in a new tab)
Meta-analysis · In vivo (Athens, Greece) · 2022 · PMID 35241506
- Effect of Soy Isoflavones on Measures of Estrogenicity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.(opens in a new tab)
Meta-analysis · Advances in nutrition (Bethesda, Md.) · 2025 · PMID 39433088
- Effects of soy isoflavones on menopausal symptoms in perimenopausal women: a systematic review and meta-analysis.(opens in a new tab)
Meta-analysis · PeerJ · 2025 · PMID 40718787
Deep research mode adds each paper’s own conclusion and stated limitations.